Real-world evidence (RWE) is derived out of real-world data (RWD) by the analysation of this kind of data. RWD is a broad concept, which depends on differing conceptualisations across its research paradigm. In the realm of ROADMAP, we have a definition of data which are coming from structured data sources, and are organised in a pyramid of evidence. These include large broad population-based databases, for example from Nordic countries, the Netherlands and UK. These are national registries and health care registries, together with available electronic medical records, data from general practitioners (GP’s) covering what is documented during daily care of patients when they are visiting the GP’s. We also have dedicated cohort data which are rich in disease-specific information, these are coming from research on patients that have dementia or AD. Last but not least, there are also data from clinical trials which one might not see as RWE, but are complementing as evidence.
What Is Real-World Data? A Review of Definitions Based on Literature and Stakeholder Interviews
Practical Implications of Using Real-World Evidence in Comparative Effectiveness Research